Biological Treatment in Meniscus Injury
Meniscal injuries, common in sports, often cause knee pain and instability. The meniscus plays a key role in pressure distribution and joint stability, making its repair essential. Treatments range from conservative approaches to surgical interventions, with growing interest in biological factors such as growth factors, mesenchymal stem cells, platelet-rich plasma, fibrin clot, and tenocyte to enhance healing. This review compares the effects of these biological agents in meniscal repair, examining their mechanisms, limitations, and clinical outcomes.
Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies
Bone fractures represent a significant global healthcare burden. Although fractures typically heal on their own, some fail to regenerate properly, leading to nonunion, a condition that causes prolonged disability, morbidity, and mortality. Biologic therapies have emerged as promising tools to enhance bone regeneration by leveraging the body's natural healing processes. This review explores the critical role of conventional and emerging biologics in fracture healing.
Source: Nature
Platelet-Rich Plasma and Knee Osteoarthritis: A Critical Overview of the Multiple Biases and Methodological Complexity
Intra-articular injections of platelet-rich plasma (PRP) are increasingly utilized in the management of knee osteoarthritis (KOA) and various other medical specialties. However, the efficacy of PRP remains a contentious issue; some experts consider it to be a placebo, while others advocate for its therapeutic value. Evidence from controlled clinical trials and meta-analyses has often yielded contradictory results, frequently failing to demonstrate a clear clinical benefit despite favorable outcomes observed in real-world settings
Source: ScienceDirect
Cast immobilisation versus surgery for unstable lateral malleolus fractures (SUPER-FIN): randomised non-inferiority clinical trial
Objective To compare cast immobilisation with surgery using open reduction and internal plate fixation for unimalleolar Weber B ankle fractures with a congruent mortise on initial radiography but deemed unstable by external rotation stress testing.
Source: thebmj
Flips, Falls, and Fractures: The Reality of Cheerleading Injuries
Cheerleading is rising in popularity, with competitive cheer now being recognized as an Olympic sport, possibly leading to an Olympic debut in the near future. These athletes present with issues such as pressure for a quick return, concerns for decreased bone density, and injury patterns unique to these athletes.
Source: AOSSM
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